23rd January
latest news: Anna's sweet and sticky pork buns

latest news

App Challenge Logo

Photo Diary app wins York prize

Friday, 20th January 2012

A group of York students has won the opportunity to have their very own I-phone application developed after winning The App Challenge final, held at the Ron Cooke Hub on Wednesday, January 18.

computer

Students warned about loans scam

Thursday, 19th January 2012

YUSU Welfare officer Bob Hughes has warned students to be vigilant after a student loans phishing scam has been revealed.

Her Most Gracious Majesty

Queen Comes to York

Wednesday, 18th January 2012

Her Majesty the Queen will be visiting York on Maundy Thursday, 5th April, as part of the 800th anniversary of York’s Charter for the traditional “Royal Maundy” ceremony.

Berrick Saul

Flooding Triggers Network Outage On Eve Of Exams

Saturday, 14th January 2012

A flood caused by a heating system “failure” forced the university IT services to shut down many essential systems on Sunday night, causing problems for many students on the eve of their exams and assignment due-dates.

more news

Red Phone
King's Manor
Aimee and Kevin the Cow
Bomb Disposal Unit
King's Manor
The Yorker Logo
christmas
Central Hall & North side of the lake

Scientists from York "Open The Door" to HIV inhibitors

Central Hall & North side of the lake
Thursday, 5th January 2012
A group of international scientists have determined the structure of the endomannosidase, significantly advancing our understanding of how the enzyme is hijacked by viruses and "opening the door to drug developments" for viruses such as HIV, which infects 3 million new people every year.

The team of international scientists, led by Professor Gideon Davies from the University of York and Associate Professor Spencer Williams from the University of Melbourne, studied bacterial endomannosidase as a model for the same human enzyme and successfully determined the three dimensional structure of the enzyme.

The viruses, including HIV, Hepatitis C, Dengue Fever and West Nile virus, use our own enzyme to attack us via two pathways, replicating themselves. For a successful treatment, both pathways need to be blocked.

Professor Davies, of the University of York's Department of Chemistry, said that "it was already known how to block the main pathway", but that the second pathway proved "a considerable challenge to study".

Dr Williams, of Melbourne University, stated that "we were able to determine the endomannosidase structure and this has revealed how we can block the bypass route, stopping the viruses from hijacking the human enzymes".

York's Professor Davies also explained how the model could be useful for science, saying that "if we understand how the viruses use our enzymes, we can develop inhibitors that block the pathway they require, opening the door to drug developments."

Professor Davies added: “We hope that the work will lead beyond viruses and will point the way towards similar treatments for other diseases including cancer.”

The research, including scientists from Oxford, the Netherlands and Austria, as well as York and Melbourne, received funding support from the Biotechnology and Biosciences Research Council (BBSRC) and the Australian Research Council.

For those who wish to know the exact structure of the enzyme, or who want to research the study, findings are published in the Proceedings of the National Academy of Sciences (PNAS) this week, and are found here.

Check out The Yorker's Twitter account for all the latest news Go to The Yorker's Fan Page on Facebook
#1 Anonymous
Mon, 9th Jan 2012 5:55pm

Awesome

Add Comment

You must log in to submit a comment.